Noninvasive differentiation of meningiomas from other brain tumours using combined111indium-octreotide/99mtechnetium-DTPA brain scintigraphy
Identifieur interne : 000035 ( Main/Exploration ); précédent : 000034; suivant : 000036Noninvasive differentiation of meningiomas from other brain tumours using combined111indium-octreotide/99mtechnetium-DTPA brain scintigraphy
Auteurs : RBID : ISTEX:701_1996_Article_BF01809748.pdfEnglish descriptors
Abstract
We have studied prospectively 47 patients with CNS tumours including 16 meningiomas and 33 other tumours using combined111In-octreotide and99mTc-DTPA brain scintigraphy.111In-octreotide scintigraphy was used to image somatostatin receptors (SSR) and99mTc-DTPA scintigraphy was used to assess the integrity of the blood-brain barrier (BBB). A total of 32 tumours (65%) were detected. All SSR positive tumours also had positive99mTc-DTPA scans and all SSR negative tumours were negative on99mTc-DTPA scans. Among the tumours located outside the BBB, all meningiomas and two out of six schwannomas were positive on combined SSR/99mTc-DTPA scintigraphy. Among the tumours located inside the BBB, seven out of nine gliomas grade I–III were negatitve, whereas all glioblastomas were positive. Other positive tumours included one malignant non-Hodgkin lymphoma and two cerebral metastases. SSR scintigraphy alone was non-specific in the diagnosis of meningiomas, as 16 non-meningiomatous tumours also had positive SSR scans probably due to a breakdown of the BBB (excluding the malignant lymphoma). Measuring the tumour-to-background ratio on SSR scans improved specificity, but sensitivity was decreased below 70% because some meningiomas were only slightly positive. Only the ratio of SSR scintigraphy to conventional99mTc-DTPA brain scintigraphy (SSR-to-BS index) allowed a reliable differentiation of meningiomas from other CNS tumours, most notably from schwannomas (sensitivity: 94%; specificity: 100%). Our results support the usefulness of combined SSR and conventional brain scintigraphy in the noninvasive pre-operative diagnosis of meningiomas.
DOI: 10.1007/BF01809748
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Reubi</name><affiliation wicri:level="1"><mods:affiliation>Institute of Pathology, University of Berne, Inselspital, Berne, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pathology, University of Berne, Inselspital, Berne</wicri:regionArea><wicri:noRegion>Berne</wicri:noRegion></affiliation></author><author><name>N. Godoy</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, University of Berne, Inselspital, Berne, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurosurgery, University of Berne, Inselspital, Berne</wicri:regionArea><wicri:noRegion>Berne</wicri:noRegion></affiliation></author><author><name>H. Rösier</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Nuclear Medicine, University of Berne, Inselspital, Berne</wicri:regionArea><wicri:noRegion>Berne</wicri:noRegion></affiliation></author><author><name>J. A. Kinser</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Nuclear Medicine, University of Berne, Inselspital, Berne</wicri:regionArea><wicri:noRegion>Berne</wicri:noRegion></affiliation></author><author><name>R. W. Seiler</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, University of Berne, Inselspital, Berne, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurosurgery, University of Berne, Inselspital, Berne</wicri:regionArea><wicri:noRegion>Berne</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:701_1996_Article_BF01809748.pdf</idno><date when="1996">1996</date><idno type="doi">10.1007/BF01809748</idno><idno type="wicri:Area/Main/Corpus">000489</idno><idno type="wicri:Area/Main/Curation">000489</idno><idno type="wicri:Area/Main/Exploration">000035</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain tumour</term><term>Meningioma</term><term>Somatostatin receptors</term><term>[111In-DTPA-D-Phel]-octreotide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">We have studied prospectively 47 patients with CNS tumours including 16 meningiomas and 33 other tumours using combined111In-octreotide and99mTc-DTPA brain scintigraphy.111In-octreotide scintigraphy was used to image somatostatin receptors (SSR) and99mTc-DTPA scintigraphy was used to assess the integrity of the blood-brain barrier (BBB). A total of 32 tumours (65%) were detected. All SSR positive tumours also had positive99mTc-DTPA scans and all SSR negative tumours were negative on99mTc-DTPA scans. Among the tumours located outside the BBB, all meningiomas and two out of six schwannomas were positive on combined SSR/99mTc-DTPA scintigraphy. Among the tumours located inside the BBB, seven out of nine gliomas grade I–III were negatitve, whereas all glioblastomas were positive. Other positive tumours included one malignant non-Hodgkin lymphoma and two cerebral metastases. SSR scintigraphy alone was non-specific in the diagnosis of meningiomas, as 16 non-meningiomatous tumours also had positive SSR scans probably due to a breakdown of the BBB (excluding the malignant lymphoma). Measuring the tumour-to-background ratio on SSR scans improved specificity, but sensitivity was decreased below 70% because some meningiomas were only slightly positive. Only the ratio of SSR scintigraphy to conventional99mTc-DTPA brain scintigraphy (SSR-to-BS index) allowed a reliable differentiation of meningiomas from other CNS tumours, most notably from schwannomas (sensitivity: 94%; specificity: 100%). Our results support the usefulness of combined SSR and conventional brain scintigraphy in the noninvasive pre-operative diagnosis of meningiomas.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="550c318a1fbd21361281c68bc2fae1905656d034"><titleInfo lang="eng"><title>Noninvasive differentiation of meningiomas from other brain tumours using combined111indium-octreotide/99mtechnetium-DTPA brain scintigraphy</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Barth</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Neurosurgery, University of Berne, Inselspital, Berne, Switzerland</affiliation></name><name type="personal"><namePart type="given">A. R.</namePart><namePart type="family">Haldemann</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland</affiliation></name><name type="personal"><namePart type="given">J. C.</namePart><namePart type="family">Reubi</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Institute of Pathology, University of Berne, Inselspital, Berne, Switzerland</affiliation></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Godoy</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Neurosurgery, University of Berne, Inselspital, Berne, Switzerland</affiliation></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Rösier</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland</affiliation></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">Kinser</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland</affiliation></name><name type="personal"><namePart type="given">R. W.</namePart><namePart type="family">Seiler</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Neurosurgery, University of Berne, Inselspital, Berne, Switzerland</affiliation></name><typeOfResource>text</typeOfResource><genre>Clinical Articles</genre><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Vienna</publisher><dateValid encoding="w3cdtf">2005-05-16</dateValid><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">We have studied prospectively 47 patients with CNS tumours including 16 meningiomas and 33 other tumours using combined111In-octreotide and99mTc-DTPA brain scintigraphy.111In-octreotide scintigraphy was used to image somatostatin receptors (SSR) and99mTc-DTPA scintigraphy was used to assess the integrity of the blood-brain barrier (BBB). A total of 32 tumours (65%) were detected. All SSR positive tumours also had positive99mTc-DTPA scans and all SSR negative tumours were negative on99mTc-DTPA scans. Among the tumours located outside the BBB, all meningiomas and two out of six schwannomas were positive on combined SSR/99mTc-DTPA scintigraphy. Among the tumours located inside the BBB, seven out of nine gliomas grade I–III were negatitve, whereas all glioblastomas were positive. Other positive tumours included one malignant non-Hodgkin lymphoma and two cerebral metastases. SSR scintigraphy alone was non-specific in the diagnosis of meningiomas, as 16 non-meningiomatous tumours also had positive SSR scans probably due to a breakdown of the BBB (excluding the malignant lymphoma). Measuring the tumour-to-background ratio on SSR scans improved specificity, but sensitivity was decreased below 70% because some meningiomas were only slightly positive. Only the ratio of SSR scintigraphy to conventional99mTc-DTPA brain scintigraphy (SSR-to-BS index) allowed a reliable differentiation of meningiomas from other CNS tumours, most notably from schwannomas (sensitivity: 94%; specificity: 100%). Our results support the usefulness of combined SSR and conventional brain scintigraphy in the noninvasive pre-operative diagnosis of meningiomas.</abstract><subject lang="eng"><genre>Keywords</genre><topic>[111In-DTPA-D-Phel]-octreotide</topic><topic>somatostatin receptors</topic><topic>meningioma</topic><topic>brain tumour</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Acta neurochir</title></titleInfo><titleInfo><title>Acta Neurochirurgica</title><subTitle>The European Journal of Neurosurgery</subTitle><partNumber>Year: 1996</partNumber><partNumber>Volume: 138</partNumber><partNumber>Number: 10</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1996-10-01</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Interventional Radiology</topic><topic>Neuroradiology</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Surgical Orthopedics</topic><topic>Minimally Invasive Surgery</topic></subject><identifier type="issn">0001-6268</identifier><identifier type="issn">Electronic: 0942-0940</identifier><identifier type="matrixNumber">701</identifier><identifier type="local">IssueArticleCount: 17</identifier><recordInfo><recordOrigin>Springer-Verlag, 1996</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF01809748</identifier><identifier type="matrixNumber">Art7</identifier><identifier type="local">BF01809748</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>1179</start><end>1185</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1996</recordOrigin><recordIdentifier>701_1996_Article_BF01809748.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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